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The standard regimen remains 20 mg orally once daily for 5 to 10 years , with the duration tailored based on recurrence risk, nodal status, and tolerability
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Additional support for this theory is found in data indicating that tricyclic antidepressants, which increase serotonin signaling, reduce the frequency of migraine attacks (Cutrer 2012)
Have gallstones or bile duct obstruction
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