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Concomitant use of semaglutide with insulin or insulin secretagogues may result in hypoglycemia, and a dose reduction in the concomitant medication may be necessary

doi: 10.1007/s12272-013-0141-3 497 InoueTNakayamaJMoriyaKKawarataniHMomodaRItoKet al

In the STEP 5 trial published in Nature Medicine, semaglutide produced an average weight loss of about 15% over two years, and many patients do exceptionally well on it

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Action Steps: Discuss with your healthcare provider about using semaglutide for diabetes or weight loss management

Most patients do not notice this change, but those with pre-existing tachycardia or certain arrhythmias may experience palpitations or discomfort