This binding is called conjugation, and glutathione is the central figure
General commentary There are many reasons as to why a preclinical study may fail to translate, particularly, poor experimental design and statistical analysis (for detailed discussions see refs
These include the incorporation of the vitamins to the liposomes (Marsanasco et al., 2011), poly(lactic-co-glycolic) acid (PLGA) nanoparticles (Gambaro et al., 2022), nanostructured lipid carriers (Saez et al., 1984), chitosan carriers (Sherif et al., 2024), nanocapsules (Khayata et al., 2012), cyclodextrin complexes (Khan et al., 2023), and peptides and antibody conjugates (Jung et al., 2018)
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Finally, based on visual inspection of the spectra, we could conclude a decrease in glutathione in the tissue after cerebral ischemia (Fig