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Interestingly, the depletion of GSH and GSSG was observed in murine liver tumors driven by MYC but not in those driven by RAS (LT2RAS model described in 24) (Fig EV1B and C)

Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells

TSPD percentage at the OMC and the sinuses was evaluated as = 100 ( M target / M spray )

No significant toxicity indicators reported during the preclinical trials

Ethics declarations Competing interests Richard D

For completeness, it is important to note that tap water is entirely unsuitable for injection and carries serious infection risks