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Both semaglutide and liraglutide are MHRA-approved and are supported by NICE technology appraisals TA875 for semaglutide and TA664 for liraglutide which set out specific eligibility criteria

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These structural data reveal a binding mode largely consistent with native amylin, but with notable differences: cagrilintide anchors via the F23 residue and forms a distinctive E14R17 intramolecular salt bridge that stabilizes its receptor-bound conformation

Post-hoc analysis of the ADAPT study has also revealed a sustained effect of efgartigimod across repeated treatment cycles, demonstrating its efficacity as a long-term treatment option [230]