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Typically, the E3 ubiquitin ligase complex comprised of Kelch-like ECH-associated protein 1-Cullin 3-Ring box 1 (KEAP1-CUL3-RBX1), S-phase kinase associated protein 1-Cullin 1-Rbx1/-transducin repeat-containing protein (SCF/-TrCP), and synonymin/Hrd1, continuously degrades Nrf2 proteasomes, maintaining Nrf2 at a low expression level [64]
However, other models (such as viral hepatitis) not summarized in this paper should be treated with caution
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They are found in things we use everyday: plastic water bottles, makeup, hair care products, receipts, carpet, non-organic foods, over-the-counter pain relievers, and a multitude of other things
Rarely, complications such as infection or color changes in the skin may occur
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