low potassium after b12 injections can cause Shots at Home: How, Where & How Often to Inject Yourself Potassium issues: Fact or fiction? – Vitamin B12 + MIC Injections

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IM administration may provide the most robust response in clinical scenarios requiring rapid or substantial metabolic correction

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Pull back (or register) the syringe to make sure that you successfully hit a vein

The difference in results between local and non-local administration remains unclear from available research

For mild deficiencies or preventative supplementation, oral pills may suffice