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Concerning glioblastoma (GBM), it has been reported that transient transfection of miR-34a mimics into glioma and medulloblastoma cell lines remarkably inhibits cell proliferation, invasion, survival, and cell cycle progression by targeting c-Met, Notch-1, and Notch-2 (Li Y

Philpot BD, Sekhar AK, Shouval HZ, Bear MF (2001)

The idea was borne out of a desire to reduce any associated high or side effects

Essentially, endurance athletes may need to override their dulled thirst mechanism to avoid performance-limiting dehydration

Common side effects include nausea, vomiting, diarrhea and constipation

DOI: 10.1007/s12602-020-09681-4