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October 22, 2024

The most extensive polymorphism is found in exon 3, a region that encodes the third intracellular loop (3IL) of the receptor ( 4 R with the respective number of repeats of a proline-rich sequence of 16 amino acids (D 4.2 R, D 4.4 R and D 4.7 R) ( DRD4 polymorphisms have been associated with individual differences in impulse control-related neuropsychiatric disorders, with the most consistent associations found between the gene encoding D 4.7 R and attention-deficit hyperactivity disorder (ADHD) ( 4 R

The reduction of PHB2 inhibits the binding of PHB2 to LC3, inhibits mitophagy, exacerbates the loss of dopaminergic neurons, and accelerates the progression of Parkinsons disease [16]

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