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Next-generation oral GLP-1 medications Orforglipron is a non-peptide oral GLP-1 receptor agonist in late-stage clinical trials

That said, there are some important caveats: Lack of human clinical trials: Rodent models represent the bulk of the available data

That is the whole reason the variant exists, and it is also the reason results obtained with it do not map cleanly onto native IGF-1 biology

There is also some evidence that the medication may contribute to worsening retinopathy, a disease affecting the retina

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95% CI 0.80, 1.00