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Crosby J, Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y, Tang ZZ, Zhang H, Hindy G, et al

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New-Onset Atrial Fibrillation in Patients With Type 2 Diabetes Treated With Novel Glucose-Lowering Therapies

Small Molecule GLP-1R Agonists Non-peptide, once-daily oral GLP-1 receptor agonistsexemplified by orforglipronare small molecules that bind the transmembrane pocket of GLP-1R and reproduce full GscAMP signaling with clinically meaningful downstream effects

(5) Navarro M, Carvajal F, Lerma-Cabrera JM, Cubero I, Picker MJ, Thiele TE

In doing this, the potential of therapies that have a significant impact on a small subset is lost within the larger sample population