Thielke, R
After being stimulated by fibrogenic factors, HSCs change from vitamin A-storing latent cells to active cells that resemble myofibroblasts, depositing an abundance of ECM, especially type I collagen
Integration used CCA on the top 3,000 variable genes, followed by PCA and clustering (resolution = 1, top 30 PCs)
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The cyclization occurs through a lactam bridge between the side chains of Asp and Lys, forming a 23-membered ring