The first dual GIP/GLP-1 receptor agonist, NNC0090-2746 (also known as RG7697, RO6811135, or MAR709), is a 40-amino acid peptide acylated with a C16:0 fatty acid to lysine residue at position 40 [ Figure 2 , Table 1 ]
While these are different trials with different designs and not a direct head-to-head comparison, the data suggests retatrutide may deliver greater weight loss
Related Reading Glp 1 For Losing Weight Tirzepatide Vs Glp 1 Glp 1 Vs Tirzepatide 2 Glp 1 For Weight Loss 2 Pricing and availability current as of June 2026
Anecdotal reports from patients taking tirzepatide have also emerged on social media platforms and patient forums describing experiences with hair thinning or increased shedding
Select GLP-1 medications may be as low as $149 without insurance and with manufacturer coupon
Cell Signaling Technology [CST]), IR (sc-711), phospho-AKT S473 (4060