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High doses of methylcobalamin are generally well tolerated but should still be used cautiously

Tomoe H and Yamashita K: Does repeated hydrodistension with transurethral fulguration for interstitial cystitis with hunner's lesion cause bladder contraction

Treat this as conservative protocol planning

Burning or stinging that intensifies with continued use, rather than diminishing, indicates genuine irritation rather than adjustment

Attach the needle to the pen

Aside from this, two of the key benefits of Methylcobalamin B vitamin injections over Cyanocobalamin injections are the greater amount of time that the former persists once it enters the body, as well as its higher potency