2 The D 4 R-modulated frontal-cortico-striatal neuron D 4 R is highly expressed in the prefrontal cortex of mammals, including rodents and human and non-human primates, particularly in deep layer neurons ( 1 R, D 2 R and in the ventral striatum, D 3 R), striatal mRNA expression of D 4 R is much lower ( 4 R produced incongruent results, particularly in relation to its striatal density, indicating a lack of antibody specificity ( 4 R gene ( Drd4 ), confirmed its predominant expression in the deep layer neurons of the prefrontal cortex and its lack of expression in the striatum ( in situ hybridization studies and indicate that striatal D 4 Rs are localized in striatal nerve terminals and, most probably in the terminals from glutamatergic neurons originated in the deep cortical layers
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