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Wilkes GM (2018) Targeted therapy: attacking cancer with molecular and immunological targeted agents
In passive intravasation tumor cells are passively shed during tumor progression as a result of a highly stressful environment ( Figure 3 ) (75)
Studies of acute GH exposure have shown increases in skeletal muscle mitochondrial oxidative capacity and upregulation of mitochondrial gene expression, indicating that upstream endocrine changes can meaningfully influence how peripheral tissues process available fuel
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But there are clinical doses that are appropriate for what you're targeting, and those change, right
It's an important data point, not necessarily an alarm bell
