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Research shows NAD+ levels drop by roughly 30% between ages 45 and 60, with some studies finding even steeper declines in older adults

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However, the prevalence of resistance is increasing worldwide and reveals important geographic differences and even the most recent and effective regimens show some critical points

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doi:10.1016/j.bcp.2019.02.008 Dimet-Wiley A, Latham CM, Brightwell CR, et al