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Notably, curcumin has demonstrated generally good tolerability even at high doses up to 12 g/day in clinical studies
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Elevated resting heart rate is an independent risk factor for adverse outcomes in heart failure, and beta-blocker therapy to reduce heart rate is a cornerstone of HFrEF management
Hyperglycemia further activates the glucoseWWP1 signaling axis, linking metabolic dysfunction to protein degradation [51, 87]
However, substantial inter-person variability exists in both weight loss efficacy and the incidence of side effects 1
