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In contrast, the significantly decreased IL-2 in sera of ALS patients at a more pronounced disease stage (42 months disease duration) demonstrated in our study strengthens potential down-regulation of this cytokine on differentiation and/or maintenance of all T cell subsets, including regulatory T cell populations, such as T helper cells, that might lead to a Th1/Th2 imbalance toward the development of an autoimmune disorder [84]

Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control sutdy of ALS in Michingan

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Acknowledgements This work was funded by a US Department of Defense (DoD) grant, a DFGGerman Research Foundation Grant, an Israeli Science Foundation (ISF) grant, an Eagles Autism Foundation grant, a National Institute of Psychobiology in Israel (NIPI) grant, an Israeli Council for Higher Education Maof Grant, and a Berettler Centre for Research in Molecular Pharmacology and Therapeutics Grant

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Titration Slowly increasing the dose over weeks instead of starting at the target dose