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For a small percentage, it is severe enough to require dose reduction or discontinuation

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[75] performed a RCT comparing mesh-augmented hiatoplasty with or without the addition of a fundoplication

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Surprisingly, the EECs in the colon have been demonstrated to physically connect through a basal process named Neuropod, with afferent nerve cells residing in the lamina propria, defining a neuroepithelial circuit that expands the physiology of these cells ( GPCRs as molecular tastants G-protein coupled receptors (GPCRs) are evolutionary ancient proteins spanning seven times across the plasma membrane of virtually any known cell type