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Semaglutide is one comparison they may consider

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The same restraint applies to other frequently overused unspecified eye codes, such as H31.9 (unspecified disorder of choroid) and H35.9 (unspecified retinal disorder)

They don't directly target the brain-gut axis the way some IBS-specific medications do, but they support the underlying gut tissue and immune signaling

doi.org/10.1007/s00775-009-0570-0 Pickart, L., et al

DSIP is a research-use peptide that has been described as modulating sleep architecture (especially slow-wave sleep) rather than acting as a sedative