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Instead of asking 'why not stack them,' the question becomes 'what specific outcome justifies adding a second compound with incomplete human safety data?' For research exploring maximal metabolic intervention where single-agent tirzepatide has plateaued, the stack may be defensible

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For 8 mg/mL: (2.5 / 8) x 100 = 31.25 units

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Diastolic blood pressure similarly improved, with mean reductions of 3-5 mmHg observed consistently across studies