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The relationship between the microbiome and sleep matters here because circadian rhythm disruption can affect appetite timing, microbial rhythms, SCFA production, and metabolic regulation
That said, if any adverse effect is suspected to be dose-related, the dose can be reduced
Participants who escalated too quickly experienced significantly higher rates of treatment discontinuation due to intolerable side effects
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"People may be scared of needles so another option like a pill may be easier for them to use long-term
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