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Up-regulation of mGlu2 receptors was observed in cultured DRG neurons isolated from 30-day acetyl-l-carnitine-treated -GalA knockout mice, which was no longer detectable in DRG neurons isolated 30 days after the end of treatment, hinting at an additional mechanism being responsible for the long-term analgesic effect [35]

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Additional risks include gallbladder disease and acute kidney injury in the setting of severe gastrointestinal adverse events