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They are not interchangeable in research design
While the BBB serves as a barrier to restrict the passage of molecules, the integrity and function of the BBB can be compromised by disease states, disease-caused inflammation, and immune responses in the brain [1, 3, 9], or even systemic infection and inflammation [10] resulting in BBB disruption and greater BBB penetration [11]
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However, this inhibition may have been reversed when Ipamorelin and ghrelin were co-presented
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