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+ B12 is a water-soluble vitamin, which means the body excretes any excess in the urine, so the safety profile is very forgiving

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While natural IGF-1 has a very short duration of action (~1520 minutes), IGF-1 LR3 remains active for up to 2030 hours , significantly enhancing its biological availability and effect on muscle tissue

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

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Symptoms include loss of appetite, tingling in hands and feet, poor memory and depression