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Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease

Diet Composition Very high-carbohydrate or low-protein diets can blunt early appetite control, especially during the first few weeks

Tirzepatide (Mounjaro, Zepbound), a dual GIP/GLP-1 receptor agonist, reports injection site reaction rates of approximately 1.7-2.2% in its FDA prescribing information, similar to semaglutide

95% CI, 1.432.20 for SGLT2i versus SGLT2i plus GLP-1RA) and GLP-1RA monotherapy (HR, 2.11

Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)