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Havelund S, Plum A, Ribel U et al (2004) The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin
Clinical Implications Based on Extraction Ratio 15 High-Extraction Drugs (High E): These drugs, by definition, have a low oral bioavailability (F is low)
One of the first indicators is a noticeable decrease in appetite, where patients feel full sooner during meals and naturally eat smaller portions
Because microdosing falls outside the dosing schedules studied in clinical trials, doctors say there are still more questions than answers
Women who use the appetite suppression period to establish healthy eating patterns, regular exercise routines, and stress management strategies are better positioned for long term success
10.2119/2007-00119.Tilg 26
