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Notably, heme oxygenase 1 (HO1), which has a dual role in regulating ferroptosis, oxidizes cellular heme to carbon monoxide, ferrous iron, and biliverdin [25]

24 TRIM proteins possess a tripartite motif (TRIM) composed of a RING domain, one or two B-box domains, and a coiled-coil region (RBCC) 24,25 and may contain additional domains

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These changes were also observed in tumor xenografts

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