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This approach aligns with broader evidence-based nutrition for metabolic health and is generally safer and more sustainable than chasing maximal suppression through unproven supplements

A nutrient-dense diet supplying methylation cofactors (folate, betaine, vitamin B12, vitamin B2, etc.) is foundational

Additionally, metformin can improve endometrial receptivity by increasing the expression of GLUT4 in the endometrium, regulating the expression of hormone receptors related to endometrial decidualization, and modulating autophagy and nucleic acid/protein transcription processes, which in turn improves the reproductive outcomes of PCOS

Hayashi N, Iida T, Yamada T, et al

Without enough reduced glutathione, these toxins can linger, leading to feelings of sluggishness or "brain fog." 2

doi: 10.3389/fimmu.2022.848886 87 TateWWalkerMSweetmanEHelliwellAPeppercornKEdgarCet al