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This divergence suggests that the protective effects identified in the pathway analysis may involve mechanisms beyond genetic proxies, such as metabolic conditions (e.g., insulin resistance, inflammation), cellular states (e.g., energy stress, mitochondrial function), and environmental factors (e.g., antiviral effects, microbiota composition changes)
Moreover, adults who were obese as children have increased mortality independent of adult weight [5], underscoring the critical importance of early intervention
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