Lixisenatide for type 2 diabetes mellitus patients inadequately controlled on oral antidiabetic drugs: a mixed-treatment comparison meta-analysis and cost-utility analysis
Based on clinically available variables (BMI, waist circumference, OGTT/HOMA-IR, lipid profiles, NAFLD assessments, androgens, SHBG, and ultrasound markers), interpretable risk stratification models should be established rather than replacing clinical logic with black-box algorithms (173, 174)
Constipation and other GI side effects are consistently worse when doses are escalated quickly
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According to the Centers for Disease Control and Prevention (CDC), 42% of American adults are considered to have obesity with an additional 31% considered overweight