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Clinical trials showed that those on the highest doses lost up to 20.9% of their body weight

There are some receptor- and ligand-specific structural features displayed by ICL2

In Arabidopsis thaliana exposed to combined high light and heat stress, anthocyanins accumulate preferentially in photosynthetically active leaf tissues experiencing elevated oxidative pressure, indicating that flavonoid deposition is coordinated with local physiological requirements rather than occurring uniformly throughout the plant (Balfagn et al., 2019)

Oxidative stress may then damage mitochondrial membranes and enzymes, further lowering ATP production and increasing the need for glutathione, SOD, catalase and other antioxidant defenses

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P.FeilchenfeldtJ.SchreiberS.PrazM.CrettenandA.GobeletC.et al (2003)