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The cyclic amide of lactivicin, is susceptible to activation by the electronegative oxygen, bonded directly to the nitrogen and the accompanying lactone moiety
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The rationale for pulsed dosing originates from Khavinson's broader theory of peptide bioregulation
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furthermore, cells with intact chromatin bridges expressing CH*:DHPH showed reduced nuclear chromatin shape-deformation and increased frequency of loose DNA bridges compared with GFP controls, indicating reduced nuclear tension (Fig
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