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Mining of the proteome data for GSH-associated genes showed that disruption of the pathway for the synthesis and degradation of glutathione in the Atggt1 (-glutamyl transpeptidase, which has a function in the degradation of GSH S-conjugates in the vacuole) knockout leaves was associated with the induction of genes encoding four GSTs in the phi class (AtGSTF2, AtGSTF6, AtGSTF9, and AtGSTF10 Ashraf et al., Moreover, shifts in the cellular glutathione redox state may reversibly modify redox-sensitive thiol groups in target proteins, either through glutathionylation or formation of cysteine cross bridges

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