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This can lead to rapid destruction of red blood cells (hemolysis) and the formation of Heinz bodies (denatured hemoglobin aggregates) in these patients

Obesity-induced inflammation and insulin resistance

Subcutaneous, in the abdomen

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice

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