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Neither naltrexone nor bupropion, the two medications that make up Contrave, carries a federal scheduling classification under the DEAs Controlled Substances Act

Newborns (especially preterm) lack the ability to metabolize benzyl alcohol, leading to metabolic acidosis, respiratory distress, hypotension and (in reported cases) the often-fatal gasping syndrome. For this reason, only preservative-free sterile water (no benzyl alcohol) is used in pediatric or neonatal care

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Brain Research, 1641 (Pt B), 207-216