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Several preclinical models and clinical studies also suggest their potential as a novel therapeutic strategy for managing pain symptoms

Quantification of heparan sulfate (HS) in Karpas299 cells transduced with a sgControl or sg PAPSS1

Arterial blood gas (ABG) analysis showed severe mixed respiratory and metabolic acidosis (pH 7.17, PCO 2 68.5 mmHg, PO 2 28.2 mmHg, HCO 3 18.8 mmol/L)

Ongoing check-ins, lab work when needed, and dose reviews are signs of safe medical oversight

Metabolic shifts may temporarily affect sleep hormones