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To confirm the involvement of ATP-sensitive K + channels in the regulation of capillary diameter by pericytes, pericytes were preconstricted for 20 min with endothelin-1 (ET1, 20 nM, applied via the capillary lumen)
This will be a Phase 2type study enrolling approximately 100 patients with moderate to severe CUD, who will receive weekly Tirzepatide or placebo over about 24 weeks
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