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The demand surge is driven almost entirely by GLP-1 peptides, where semaglutide, tirzepatide, and the next-wave candidates have created order volumes that substantially exceed historical peptide manufacturing capacity

La activacin de GLP-1R en clulas pancreticas potencia la secrecin de insulina dependiente de glucosa y suprime glucagn, mientras que la sealizacin GLP-1R en ncleos hipotalmicos (arcuato, NTS) reduce la ingesta calrica

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Lancet Diabetes Endocrinol 5(5):355366 Lingvay I, Catarig AM, Frias JP, Kumar H, Lausvig NL, le Roux CW, Thielke D, Viljoen A, McCrimmon RJ (2019) Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial

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