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NADPH is mainly derived from the pentose phosphate pathway, which uses glucose-6-phosphate dehydrogenase (G6PD) as the key enzyme [36]

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These results highlight the significant benefits of adding tirzepatide to insulin therapy, offering improved glycemic control and meaningful weight loss in patients with T2DM who are inadequately controlled on insulin glargine alone [72]

We remark that one would not expect the contributions of the two metabolites to GSH synthesis to be strictly proportional to their inputs since they are used in other reactions and the system is highly non-linear

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Response To "Superior Cerebrovascular Outcomes with Tirzepatide Versus Semaglutide: A Call for Cautious Interpretation of Observational Data"