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We then excluded patients that met any of the following criteria: (1) diagnosis with related disorders of the eyes excluding the retina based on the ICD-9 and ICD-10 codes (Additional file 1: Table S4)

Lean mass includes muscle, organs, bone, water, and other non-fat tissues

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Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

The rate follows Arrhenius kinetics: every 10 degree C rise roughly doubles the degradation rate