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Co-primary endpoints encompassed the percentage alteration in body weight from baseline to week 104 and the attainment of weight loss equivalent to or greater than 5% of baseline weight at week 104

DOI: 10.3390/antiox9100941 Estruch, R., Ros, E., Salas-Salvado, J., et al

Semaglutide, with its 165-hour half-life, requires only a weekly injection

GLP-1R activation of neuroprotective pathways in neurons, microglia and astrocytes has also been reported: improvements in overall cognition, learning and motor function potentially associated with GLP-1RA administration in Alzheimers disease and Parkinsons disease may be mediated not only by their amyloid pathology-ameliorating properties (A, tau and -synuclein), but also the suppression of Ca 2+ deregulation and endoplasmic reticulum stress, anti-inflammatory activity, blockage of oxidative stress, mitochondrial dysfunction and apoptosis pathways, enhancements in the neuronal insulin sensitivity and energy metabolism, functional improvements in autophagy and mitophagy, elevated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis, and neurogenesis 36

10.1111/j.1463-1326.2011.01511.x Diabetes Obes

The concern here is different: will the extended interval cause breakthrough symptoms