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However, preclinical models for immunogenicity research are limited by three factors 1) the native peptides that are the focus of drug development may have slightly different sequences that could impact immune responses to the API, 2) The MHC molecules that are engaged in the immune responses may have different MHC-binding motif preferences (different side chains bind to the binding pockets), and 3) cross-conservation of the peptide with other peptide epitopes in the genome of the in vivo model system being used may be different enough to affect the tolerogenicity profile of the drug
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Any foodservice strategy that does not account for this cohort is working with incomplete information
