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The MAS comprises MDH1/2, GOT1/2, the malate--KG antiporter and the glutamate-aspartate antiporter, which exchanges mitochondrial -KG for cytosolic malate that is synthesized from oxaloacetic acid (OAA) by cytosolic MDH (Fig

Peer review Peer review information Nature Reviews Molecular Cell Biology thanks Fudi Wang, Jos Pedro Friedmann Angeli and Qitao Ran for their contribution to the peer review of this work

In inverse circumstances, the hypothalamus reduces the CRH and ACTH hormonal output to decrease the overall cortisol levels.16 As the National Center for Biotechnology Information explains, the system works in a "diurnal circadian pattern," meaning a 24-hour cycle most active in the daytime

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Tirzepatide (Mounjaro/Zepbound) is sometimes discussed separately because it is a dual agonist