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Administration Methods Injection : Subcutaneous or intramuscular injections, typically near the site of injury or inflammation, provide quicker delivery to the affected area

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Immunohistochemical staining for Nrf2, NQO1, and HO-1 expression on knee joint histological sections demonstrated that metformin administration significantly increased the numbers of Nrf2, NQO1, and HO-1-positive chondrocytes compared to those in OA group (Fig

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