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The HBOT SPECT brain blood flow and associated clinical improvements may have resulted, in part, from Nrf2-induced increases in astrocyte GSH

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In addition, exposure to exogenous hydrogen peroxide can activate iron response elements involved in the regulation of iron metabolism by binding to mRNA, which can inhibit the translation of ferritin and reduce ferritin synthesis, thus increasing the concentration of free iron in cells

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[4] [5] When administered intravenously or intramuscularly, exogenous glutathione is rapidly distributed in the plasma, where it may be oxidized or broken down into its constituent amino acids

Furthermore, the risk of an allergic reaction is typically lower with oral supplements than with injections