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Clinical trials with over 10,000 participants showed cancer incidence rates comparable to control groups, though rodent studies identified thyroid C-cell tumors leading to FDA warnings

Some patients lose significant weight without feeling cold, while others experience chills early then warm up as their body stabilizes

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Important safety information: These medications carry a boxed warning about the risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)