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Key findings from early trials include: Sustained weight loss over nearly one year of treatment Improvements in blood sugar control, with many participants achieving normal HbA1c levels Reduced liver fat content, beneficial for metabolic health Generally well-tolerated side effect profile These results represent some of the most substantial weight loss outcomes observed in clinical trials for obesity medications

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One peptide contains a hydrophobic sequence at its N-terminus (PFVYLI-CAND) 44 , while the other includes a positively charged, hydrophilic HIV-TAT sequence at its N-terminus (CPP-CAND) 45 (Figure