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Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice

In these contexts, astrocytes may shift from a neuroprotective role to one that exacerbates neuronal dysfunction, potentially due to downregulated expression of lactate dehydrogenase A (LDHA), a key glycolytic enzyme, which impairs lactate shuttling by inhibiting large conductance Ca 2+ activated potassium channel (BK channel)-mediated neuronal hyperpolarization (Yao et al., 2023)

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Exposure to these types of endocrine chemical disruptors during pregnancy could alter the proliferative activity and cell potency in both populations of NSPCs, but their effects could be reflected only later in life